Serum Resistin Level Following Non-surgical Periodontal Therapy in Diabetic Patients With Chronic Periodontitis

Cairo University30 enrolled

Overview

non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.

Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis. Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Type2 Diabetes

Interventions

non-surgical periodontal therapyPROCEDURE

supra and subgingival debridement

Eligibility

Sex: ALLMin age: 40 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosed with moderate to severe chronic periodontitis. * Presence of a minimum of 15 natural teeth * Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm * agreement to participate in the study and sign a written informed consent Exclusion Criteria: * Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation * A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months * Pregnancy or use of contraceptives or any medication related to diabetes * former or current smokers ˂ 5 years.

Locations (1)

Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

serum resistin

ng/ml

Time frame: 3 months

Secondary Outcomes

C-reactive protein

μg/mL

Time frame: 3 months

probing pocket depth

Time frame: 3 months

clinical attachment loss

Time frame: 3 months

Data from ClinicalTrials.gov

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