This study investigates the influence of type of anesthesia on postoperative renal dysfunction in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics using desflurane.
Nephrectomy is considered as a standard therapy for renal cell carcinoma, but it can cause postoperative renal dysfunction, such as acute kidney injury and chronic kidney disease. Therefore, it is imperative to identify modifiable risk factors for postoperative acute kidney injury after nephrectomy in advance. According to a recent retrospective study, total intravenous anesthesia using propofol is significantly associated with lower incidence of acute kidney injury after nephrectomy, compared to the inhalation anesthesia. However, there is no prospective study which investigates the influence of type of anesthesia on postoperative renal function after nephrectomy. Therefore, in the present study, we aimed to investigate the influence of type of anesthesia on acute kidney injury after nephrectomy by performing randomized controlled study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
324
The induction and maintenance of anesthesia was performed by total intravenous anesthesia using propofol. In both groups, remifentanil is continuously infused throughout the surgery.
The induction and maintenance of anesthesia was performed by inhalation anesthesia using desflurane. In both groups, remifentanil is continuously infused throughout the surgery.
Seoul National University Hospital
Seoul, South Korea
the incidence of acute kidney injury
acute kidney injury (diagnosed by KDIGO criteria)
Time frame: during the postoperative seven days
serum creatinine
postoperative result of serum creatinine
Time frame: postoperative day 1, 3, 14
estimated glomerular filtration rate
postoperative result of estimated glomerular filtration rate
Time frame: postoperative day 1, 3, 14
biomarker of renal injury
postoperative result of biomarker of renal injury
Time frame: postoperative day 1, 3, 14
the incidence of postoperative complications
urine leakage, prolonged ileus, wound infection, retroperitoneal abscess, pneumonia, reoperation, etc.
Time frame: during the postoperative two weeks
Length of hospital stay
length of hospital stay
Time frame: during the postoperative two weeks
Length of intensive care unit stay
length of intensive care unit stay
Time frame: during the postoperative two weeks
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