Sympathoinhibition as a Preferred Second Line Treatment of Obesity Related Hypertension

Inclusion Criteria: * Age: 25 -70 years * (Body Mass Index) BMI≥30kg/m2 * Currently weight stable (+/- 3% in previous 6-12 months and not on any specific exercise or dietary program) * Elevated clinic systolic (Blood Pressure) BP ≥135 or diastolic BP ≥85mmHg, * on ACE inhibitor for at least 6 weeks prior to baseline assessment Exclusion Criteria: * Grade 2-3 hypertension (systolic office BP \>160, diastolic office BP \>100 mmHg) * Secondary causes of hypertension * CKD (Chronic kidney disease) stage 4-5 {(estimated glomerular filtration) eGFR\<30ml/min} * Heart failure NYHA (New York Heart Association) class II-IV * Recent CV (cardiovascular) event (acute myocardial infarction, acute coronary syndrome, stroke or transient ischaemic attack within the previous six months) unstable psychiatric condition * medication such as corticosteroids, several antidepressants and antipsychotics * Female participants of childbearing potential must have a negative pregnancy test prior to treatment