Safety and Effectiveness Assessment of the MakAir Artificial Ventilator

Inclusion Criteria: Sequence 1 : * Patient for whom a certificate has been signed by a support person / family member / close relative independent of the sponsor. * Adult * Non-hypoxemic patient (PaO2 / FiO2\> 300) * Patient requiring invasive mechanical ventilation\> 24 hours * Stabilized patient, i.e. not needing an increase in oxygenation for at least 6 hours Sequence 2 : * Patient for whom a certificate of consent has been signed by a support person / family member / close relative independent of the sponsor. * Adult * Patient with mild to moderate Acute respiratory distress syndrome (300\> Pa02 / FiO2\> 100) * Patient requiring invasive mechanical ventilation\> 3 days * Stabilized patient, i.e. having not required an increase in oxygenation for at least 6 hours Sequence3 : * Patient for whom a certificate of consent has been signed by a support person / family member / close relative independent of the sponsor or waiver due to life-threatening emergency. * Adult * Patient with mild to moderate Acute respiratory distress syndrome (PaO2 / FiO2\> 100) or without Acute respiratory distress syndrome * Patient requiring invasive mechanical ventilation for any duration * Situation of shortage among centers investigating technical devices for invasive ventilation to treat all patients Exclusion Criteria: Sequence 1 and sequence 2: * Patient positive or showing signs of Covid-19 infection * Tracheotomized patient * History of pulmonary emphysema or severe to moderate chronic obstructive pulmonary disease * Patient in recovery and withdrawal phase of ventilatory assistance * Pneumothorax or pneumomediastinum * Hemodynamic instability * Intracranial hypertension * Pregnant woman (A urine or blood pregnancy test must be performed for women of childbearing age) * Major protected (guardianship, curatorship and under the protection of justice) * Lack of affiliation to the French social security system * Participation in another interventional clinical trial Sequence3 : * Tracheotomized patient * History of pulmonary emphysema or severe to moderate moderate chronic obstructive pulmonary disease * Patient in recovery and withdrawal phase of ventilatory assistance * Pneumothorax or pneumomediastinum * Hemodynamic instability * Intracranial hypertension * Pregnant woman (A urine or blood pregnancy test must be performed for women of childbearing age) * Major protected (guardianship, curatorship and under the protection of justice) * Lack of affiliation to the French social security system * Participation in another interventional clinical trial on mechanical ventilation