4-step ASCOT in POI Women to Promote Follicular Rescue

Inclusion Criteria: * Subjects who meet the following will be considered eligible to participate in the clinical trial: 1. Informed consent form dated and signed. 2. Age between 18 and 38 (both inclusive) 3. Women who meet the ESHRE criteria for POI \[41\] * presence of menstrual disturbance defined as oligo/amenorrhea for at least 4 months * biochemical confirmation as evidenced by an elevated FSH level \>25IU/L on two occasions \> 4 weeks apart * Or fluctuating POI when one of the above criteria is missing. Exclusion Criteria: * Subjects who meet one or more of the following will not be considered eligible to participate in the clinical trial: 1. Simultaneous participation in another clinical study that, at the researcher's criteria, could interfere with the results of this study. 2. Age ≥ 39 3. Autoimmune origin of POI 4. Genetic risk factors for POR (e.g. Turner Syndrome, FMR1 premutation, etc); 5. Acquired conditions associated with POR (e.g. Chemotherapy); 6. Clinical endometriosis 7. Previous ovarian surgery considered as a risk of POR 8. Previous gonadotoxic treatment 9. Known intolerance or allergic reactions to components of the study product, i.e. lactose