Intravascular Ultrasound Versus Angiography Guided Drug-coated Balloon Treatment for STEMI Patients：a Prospective, Multicenter, Randomized Controlled Trial

Inclusion Criteria: * Acute myocardial infarction eligible for PPCI: 1. \>20 min of chest-pain and at least 1 mm ST-elevation in at least two contiguous leads, a new left bundle branch block or a true posterior myocardial infarction (confirmed by ECG or echocardiography) . 2. Reperfusion is expected to be feasible within 12 h after onset of complaints. * Infarct related artery eligible for PPCI and: 1. De novo lesion in a native coronary artery 2. Reference-vessel diameter 2.5 mm and 4 mm 3. Diameter stenosis of \>50% (by visual assessment) after thrombus aspiration and pre-dilatation. Exclusion Criteria: * \- Age \<18 yr and \>85 yr * History of myocardial infarction * lesion length \> 30m * Left Main lesion * Ostial lesion * None-target vessel need to treat with PCI * Severe calcification * Severe tortuosity * Severe angulation * Cardiogenic shock before pre-dilation or any serious cases can not perform IVUS * Known contraindication/resistance for bivalirudin, fondaparinux, heparin, aspirin, prasugrel and/or ticagrelor * Participation in another clinical study, interfering with this protocol Uncertain * Known intracranial disease (mass, aneurysm, AVM, haemorrhagic CVA, ischemic CVA/TIA \<6 months before inclusion or ischemic CVA with permanent neurological deficit) Gastrointestinal/urinary tract * bleeding \<2 months before inclusion Refusal to receive blood transfusion * Planned major surgery within 6 weeks * Stent implantation \<1 week before inclusion * Expected mortality from any cause within the next 12 months