Malnutrition and loss of muscle mass frequently occur in patients undergoing chemotherapy and can negatively effect therapy outcome. Especially patients with cancer of the gastrointestinal tract are often affected by malnutrition. Therefore, this study aims to examine changes in nutritional status of patients with cancer of the gastrointestinal tract during chemotherapy. Findings of this study will help to improve nutritional treatment of patients undergoing chemotherapy.
Malnutrition and sarcopenia are common complications in patients with malignant diseases of the gastrointestinal tract. During chemotherapy there is a high risk of further impairment of nutritional status due to anorexia, nausea, emesis and other gastrointestinal conditions that adversely impact food assimilation or absorption. Findings on changes of nutritional status during chemotherapy are scarce but of paramount importance for adequate nutrition therapy. Therefore, this study aims to provide a detailed description of changes in nutritional status of patients with a malignant condition of the gastrointestinal tract during chemotherapy.
Study Type
OBSERVATIONAL
Enrollment
66
No intervention - observational study only
University Medicine Greifswald
Greifswald, Germany
Prevalence of Malnutrition According to the Global Leadership Initiative on Malnutrition criteria (GLIM criteria)
Change in prevalence of malnutrition according to the GLIM criteria
Time frame: 3 months after study enrollment
Prevalence of Malnutrition According to the European Society for Clinical Nutrition and Metabolism criteria (ESPEN criteria)
Change in prevalence of malnutrition according to the ESPEN criteria
Time frame: 3 months after study enrollment
Skeletal Muscle Mass
Changes in the skeletal muscle mass measured by Bioelectrical Impedance Analysis (BIA)
Time frame: 3 months after study enrollment
Fat Free Mass
Changes in the fat free mass measured by Bioelectrical Impedance Analysis (BIA)
Time frame: 3 months after study enrollment
Fat Mass
Changes in the fat mass measured by Bioelectrical Impedance Analysis (BIA)
Time frame: 3 months after study enrollment
Total Body Water
Changes in the total Body water measured by Bioelectrical Impedance Analysis (BIA)
Time frame: 3 months after study enrollment
Extracellular Water
Changes in the total extracellular water measured by Bioelectrical Impedance Analysis (BIA)
Time frame: 3 months after study enrollment
Phase Angle
Changes in the phase angle measured by Bioelectrical Impedance Analysis (BIA)
Time frame: 3 months after study enrollment
Body Weight
Changes in body weight measured in kilograms
Time frame: 3 months after study enrollment
Height
Changes in height measured in meters
Time frame: 3 months after study enrollment
Body Mass Index
Changes in body mass index in kg/m\^2 (calculated from the values obtained for body weight and height)
Time frame: 3 months after study enrollment
Waist Circumference
Changes in waist circumference measured in centimeters
Time frame: 3 months after study enrollment
Hip Circumference
Changes in hip circumference measured in centimeters
Time frame: 3 months after study enrollment
Waist-to-Hip Ratio
Changes in waist-to-hip ratio (calculated from the values obtained for waist and hip circumference)
Time frame: 3 months after study enrollment
Upper Arm Circumference
Changes in upper arm circumference measured in centimeters
Time frame: 3 months after study enrollment
Triceps Skinfold Thickness
Changes in triceps skinfold thickness measured in millimeters
Time frame: 3 months after study enrollment
Muscle Strength
Changes in muscle strength measured by a handgrip strength dynamometer
Time frame: 3 months after study enrollment
Muscle Function
Changes in muscle function measured by a 4-m gait speed test
Time frame: 3 months after study enrollment
Sarcopenia According to the European Working Group on Sarcopenia in Older People 2 criteria (EWGSOP2 criteria)
Change in prevalence of sarcopenia according to the EWGSOP2 criteria
Time frame: 3 months after study enrollment
Energy Intake
Changes in energy intake assessed by 3-day weighed dietary record
Time frame: 3 months after study enrollment
Protein Intake
Changes in protein intake (in g/day) assessed by 3-day weighed dietary record
Time frame: 3 months after study enrollment
Carbohydrate Intake
Changes in carbohydrate intake (in g/day) assessed by 3-day weighed dietary record
Time frame: 3 months after study enrollment
Fat Intake
Changes in fat intake (in g/day) assessed by 3-day weighed dietary record
Time frame: 3 months after study enrollment
Dietary Fiber Intake
Changes in dietary fiber intake (in g/day) assessed by 3-day weighed dietary record
Time frame: 3 months after study enrollment
Physical Activity
Changes in metabolic equivalent of task per day and activity level are assessed by employment of the German version of the International Physical Activity Questionnaire (IPAQ) Short Form
Time frame: 3 months after study enrollment
Complete Blood Count
Changes in complete blood count
Time frame: 3 months after study enrollment
Albumin
Changes in plasma concentration of albumin
Time frame: 3 months after study enrollment
Aspartate Transaminase
Changes in plasma concentration of aspartate transferase
Time frame: 3 months after study enrollment
Alanine Aminotransferase
Changes in plasma concentration of alanine aminotransferase
Time frame: 3 months after study enrollment
Gamma-glutamyl Transferase
Changes in plasma concentration of gamma-glutamyl transferase
Time frame: 3 months after study enrollment
Bilirubin
Changes in plasma concentration of bilirubin
Time frame: 3 months after study enrollment
Creatinine
Changes in plasma concentration of creatinine
Time frame: 3 months after study enrollment
Urea
Changes in plasma concentration of urea
Time frame: 3 months after study enrollment
C-reactive Protein
Changes in plasma concentration of C-reactive protein
Time frame: 3 months after study enrollment
Plasma Metabolome
Changes in plasma metabolome
Time frame: 3 months after study enrollment
Plasma Transcriptome
Changes in plasma transcriptome
Time frame: 3 months after study enrollment
Intestinal Microbiome
Changes in intestinal microbiome
Time frame: 3 months after study enrollment
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