Inosine Energy Expenditure Study

University Hospital, Basel, Switzerland8 enrolled

Overview

Investigators want to test whether the intake of the nucleoside inosine increases the human energy expenditure. Inosine occurs as a metabolic intermediate in the human body and is sometimes taken as a dietary supplement by athletes. For this purpose, investigators will measure the basal metabolic rate by indirect calorimetry. Study participants will then take inosine dissolved in water or placebo and energy expenditure will be assessed again.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy Volunteers

Interventions

InosineDIETARY_SUPPLEMENT

2 grams of inosine dissolved in 250 ml water taken by mouth

PlaceboOTHER

250 ml water taken by mouth

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy male volunteers * BMI between 18-27 kg/m2 * Age between 18 and 40 years Exclusion Criteria: * Chronic concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus), * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the study * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Previous enrolment into the current study, * Enrolment of the investigator, his/her family members, employees and other dependent persons, * Thyroid disorders

Locations (1)

University Hospital Basel, Department of Endocrinology

Basel, Canton of Basel-City, Switzerland

Outcomes

Primary Outcomes

resting energy expenditure after Inosine

resting energy expenditure (REE) assessed by indirect calorimetry after oral intake of two grams of inosine as compared to placebo

Time frame: one hour after oral intake of inosine

Secondary Outcomes

Change in energy expenditure

\- Difference in EE between baseline measurement and measurement one hour after administration of inosine or control, respectively, at each study visit.

Time frame: one hour after oral intake of inosine

Change in Respiratory Quotient

\- Respiratory quotient (RQ) as an indicator of substrate oxidation one hour after oral intake of two grams of inosine

Time frame: one hour after oral intake of inosine

Serum inosine level

Serum inosine levels after ingestion of inosine

Time frame: 0 hours, 1 hour, 2 hours

Data from ClinicalTrials.gov

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