Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L in Children

Cairo University10 enrolled

Overview

The aim of the present study is to evaluate and compare the anesthetic efficacy of Alexadricaine versus Mepecaine-L infiltration anesthesia in children during extraction of badly decayed or unrestorable maxillary first primary molars.

To our knowledge, no clinical trials in literature have been done to compare anesthetic efficacy of 4% Articaine versus 2% Mepivacaine in pain management during extraction of badly decayed upper first primary molars. Thus, the purpose of the present study was to fill this knowledge gap. This trial will be held on a new brand of 4% articaine made in Egypt called Alexadricaine anesthetic solution where no clinical trials have been conducted on it yet in literature.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Local Anesthesia

Interventions

4% Articaine Hydrochloride with 1:100,000 AdrenalineDRUG

new Egyptian articane anesthetic solution.

2% Mepivacaine Hydrochloride with 1:20,000 LevonordefrinDRUG

Mepecaine-L is the brand name of the Egyptian 2% Mepivacaine. It is the most commonly used anesthetic solution in Egypt due to its availability and its lower cost.

Eligibility

Sex: ALLMin age: 5 YearsMax age: 7 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Medically fit (ASA I, II). * Mentally capable of communication. * Children aged 5-7 years, children older than 8 years old will not be included due to physiologic root resorption associated with shedding which may simplify the extraction procedure(25). * First maxillary primary molar needs extraction due to root caries "beyond possible repair". * First dental visit. * Child must give assent prior to participation, as well as approved parental informed written consent. Exclusion Criteria: * Children with acute or sub-acute dento-alveolar abscess Children with history of prolonged bleeding, platelet disorders, Hyperthyroidism or hypersensitivity. * Patients who had taken analgesics or antibiotics in the 12-hrs preceding the injection.

Locations (1)

Faculty of dentistry cairo university

Cairo, Egypt

Outcomes

Primary Outcomes

Intra-operative pain during extraction

measured by Visual Analogue Scale (VAS) and Sound Eye Motor (SEM) scale

Time frame: through study completion, an average of 1 year

Secondary Outcomes

onset of anesthesia

measured in minutes using stopwatch

Time frame: through study completion, an average of 1 year

duration of anesthesia

measured in minutes using stopwatch

Time frame: through study completion, an average of 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.