Clonal Hematopoiesis of Indeterminate Potential in Venous Thromboembolism

Centre Hospitalier Universitaire de Nīmes150 enrolled

Overview

The aim of the study is to investigate the existence of clonal hematopoiesis of indeterminate potential (CHIP) in patients with a history of venous thromboembolism. The study investigators make the assumption that these patients present mutations involved in CHIP occurrence.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Venous Thromboembolism

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women over 50 years old who have consulted at the Hematology laboratory of the Nîmes University Hospital for the occurrence or history of venous thromboembolism * Patient who has accepted that their DNA was kept and used in the context of research on venous thromboembolism (biobank (registration number DC-2008-290 and authorization number AC-2008-107)) Exclusion Criteria: * Patients less than 50 years old * Patient who has refused that their DNA was kept and used in the context of research on venous thromboembolism

Locations (1)

CHU de Nimes

Nîmes, France

Outcomes

Primary Outcomes

DNMT3A mutations screening

Next generation sequencing

Time frame: For sequencing analysis: 2 months

Secondary Outcomes

TET2, ASXL1, TP53, JAK2, SF3B1, SRSF2, GNB1, CBL, BCOR, SH2B3, PPM1D mutations screening

Next generation sequencing

Time frame: For sequencing analysis: 2 months

Data from ClinicalTrials.gov

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