Protein Classifier for Thyroid Indeterminate Nodules

Inclusion Criteria: 1. Patients with aged 18 to 70 years old; 2. Patients with thyroid nodules who have not been treated with drugs; 3. Patients who were diagnosed as Bethesda III and IV by cytology and pathology before operation; 4. Patients who underwent total / partial thyroidectomy and had histopathological reports of corresponding cellular pathological punctured nodules; 5. Patients voluntarily participate in the study after informed consent. Exclusion Criteria: 1. Patients without operation; 2. Patients with insufficient FNA sample size (judged by the laboratory).