Comparison of Imaging Characteristics of uEXPLORER and Conventional PET/CT in Patients With Lung Cancer, Lymphoma, and Melanoma

N/AActive Not RecruitingNCT04478318

University of California, Davis180 enrolled

Overview

To determine the minimum scan duration for fluorine-18 positron-emitting radioactive isotope-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scans performed on a total-body PET/CT scanner that results in non-inferior image quality to 18F-FDG PET/CT scans performed on a conventional PET/CT scanner. The subject population will be patients being staged for lung cancer, lymphoma, or melanoma.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

180

Conditions

Lung Neoplasm Lymphoma Melanoma Fluorodeoxyglucose Positron-emission Tomography

uEXPLORER/mCTDEVICE

Participants will undergo a total-body PET/CT scan with the uEXPLORER scanner first, followed by a PET/CT scan with the conventional mCT PET/CT scanner.

mCT/uEXPLORERDEVICE

Participants will undergo a PET/CT scan with the conventional mCT PET/CT scanner, followed by a total-body PET/CT scan with the uEXPLORER scanner

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Ability to understand and willingness to sign an informed consent form. 2. Ability to adhere to the study visit schedule and all protocol requirements. 3. Men and women ≥18 years of age. 4. Diagnosis or suspected diagnosis of lung cancer, melanoma or lymphoma. 5. Patients who have been referred for a PET/CT scan. Exclusion Criteria: 1. Pregnant women. 2. Claustrophobia. 3. Any significant medical condition that in the opinion of the investigator would prevent the subject from participating and/or adhering to study related procedures or interfere with subject safety.

Outcomes

Primary Outcomes

Minimum scan duration on a total-body PET/CT scanner for quality

To determine the minimum scan duration for 18F-FDG PET/CT scans performed on a total-body PET/CT scanner that results in non-inferior image quality to 18F-FDG PET/CT scans performed on a conventional PET/CT scanner over 20 minutes.

Time frame: One imaging visit up to two hours

Secondary Outcomes

Minimum scan duration on a total-body PET/CT scanner for tumor recognition

To determine the minimum scan duration for 18F-FDG PET/CT scans performed on a total-body PET/CT scanner that results in non-inferior tumor conspicuity to 18F-FDG PET/CT scans performed on a conventional PET/CT scanner over 20 minutes (with an additional 2 minutes of data used for optimization purposes).