CD7-CART in the Treatment of r / r CD7 Positive Hemolymph System Malignancies on Increasing Dose and Open Label Study

Inclusion Criteria: * The age ranged from 7 to 70 years (including the cut-off value), regardless of gender * The expected survival time was more than 6 weeks * ECOG score 0-1 * Malignant lymphoma (including but not limited to acute T-lymphoblastic leukemia / lymphoma; extramedullary NK / T-cell lymphoma, nasal type; peripheral T-cell lymphoma, nonspecific; vascular immunoblastic T-cell lymphoma; intestinal disease associated T-cell lymphomas; anaplastic large cell lymphoma (ALK -); T-cell lymphoblastic leukemia) * When screening, hematological malignancies with CD7 Positive confirmed by bone marrow examination or tumor pathology with positive rate of CD7 ≥ 30%, meeting one of the following conditions: 1. At least two chemotherapy regimens failed or did not achieve complete remission or relapse; 2. Patients who relapsed after stem cell transplantation were not affected by other treatment methods; * For peripheral blood involved acute T-lymphoblastic leukemia / lymphoma and NK / T-cell lymphoma, patients with TCR rearrangement were detected by ngs * The liver and kidney function, heart and lung function meet the following requirements: 1. Creatinine ≤ 1.5 ULN; 2. LVEF ≥ 45%; 3. Blood oxygen saturation \> 91%; 4. The total bilirubin ≤ 2 × ULN; ALT and AST ≤ 2.5 × ULN; the abnormal ALT and AST caused by diseases (such as liver infiltration or bile duct obstruction) can be relaxed to ≤ 5 × ULN; * Understand the experiment and have signed the informed consent Exclusion Criteria: * Those who need immunosuppressant; * For intestinal disease-related T-cell lymphoma, patients with intestinal ulcer or hematochezia were examined by colonoscopy; * In addition to cervical carcinoma in situ, basal cell or squamous cell skin cancer, local prostate cancer after radical operation, and breast ductal carcinoma in situ after radical operation; * The patients with positive HBsAg or HBcAb and HBV DNA titer in peripheral blood were not within the normal reference value; those with positive anti HCV antibody and positive HCV RNA in peripheral blood; those with HIV antibody positive and cytomegalovirus DNA positive Syphilis was positive; * Severe heart disease: including but not limited to unstable angina pectoris, myocardial infarction (within 6 months before screening), congestive heart failure (NYHA classification ≥ III), severe arrhythmia; * Unstable systemic diseases judged by researchers: including but not limited to severe liver, kidney or metabolic diseases requiring drug treatment; * Within 7 days before screening, there were active or uncontrollable infections requiring systemic treatment (except for mild genitourinary system infection and upper respiratory tract infection); * Pregnant or lactating women, female subjects planning pregnancy within 1 year after cell reinfusion or male subjects whose partners plan to conceive within 1 year after cell reinfusion; * Patients who had received car-t therapy or other gene modified cell therapy before screening; * Subjects who were receiving systemic steroid therapy or were receiving systemic steroid therapy for 7 days were excluded; * Participated in other clinical studies within 3 months before screening; * There was evidence of central nervous system invasion during screening; * According to the judgment of the researchers, it does not conform to the condition of cell preparation; * Other researchers think it is not suitable to be included in the study.