Meclizine Plasma Levels in Responders and Non-responders

Medical Corps, Israel Defense Force50 enrolled

Overview

Motion sickness is a debilitating condition that can effect many crew members. Meclizine has long been known as an effective anti motion sickness drug. The response to the drug is variable - some are responders, while others are resistant to the drug. The aim of the present study is to examine whether there is a correlation between meclizine plasma levels and clinical response.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Seasickness Meclizine

Interventions

Meclizine HydrochlorideDRUG

Meclzine is given to all study participants to prevent seasickness. Meclizine plasma levels are determined from both the meclizine responders and non responders group.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Seasickness questioner (WIKER) score of 7. * Subjective functioning at 1 meter sea voyage - 5/10 and lower. * Subjects who were prescribed 25mg of meclizine. * Subjects who did not take any other drugs 48 prior to their participation in the study. Exclusion Criteria: * Known hearing loss or any vestibular impairment * Vertigo complains * Any ear infection * Use of Scopolamine based anti-seasickness drugs. * Use of meclizine 50mg.

Outcomes

Primary Outcomes

Meclizine plasma levels

ng/dl

Time frame: 2 hours after meclizine administration

Central Contacts

Yoni Evgeni Gutkovich, M.D/Ph.D

CONTACT

+972526894497 gutkovichj@gmail.com

Dror Tal, Ph.D

CONTACT

+972549096080 tldror1@gmail.com

Data from ClinicalTrials.gov

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