Precision medicine is to achieve individual optimal health care, given the biological mechanisms, genetic variants, and environmental measurements. Take mood disorder (MD) as an example, we aim to develop systems and precision medicine in Taiwanese population. MD is a very serious and dysfunctional mental disorder. Since MD patients with treatment have high risk of neurocognitive impairment and metabolic disturbances, the therapeutic strategies are of clinical importance. Individual difference of treatment outcome in MD patients would result from genetic variants, environmental factors, and their interactions. Also, the treatment outcome of MD contains multiple dimensions, including improvement of disease severity, neurocognitive function, and optimized medication strategy. However, comprehensive development of approaches to investigate the multiple dimensions of treatment outcome in MD patients is limited. In this three-year proposal, we explore the interactions of genetic variants and environmental factors (represented by psychosocial stress and gut microbiota) driven approaches to develop precision medicine.
Study Type
OBSERVATIONAL
Enrollment
200
National Cheng Kung University (NCKU) Hospital
Tainan, Taiwan
RECRUITINGDepression severity
Clinician rated score by Structure Interview Guide for the Hamilton Depression Rating Scale (17-item)
Time frame: six months
The influence of environmental factor in mood disorder
Collect the DNA of fecal flora to test the diversity and abundance of gut microbiota
Time frame: six months
cognitive function assessed using the Finger Tapping Test (FTT)
Time frame: six months
cognitive function assessed using Wisconsin Card Sorting Test (WCST)
Time frame: six months
cognitive function assessed using Continuous Performance Test (CPT)
Time frame: six months
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