MDR-TB Close Contacts Tracing in China (TCCT Study)

The index patient: Inclusion Criteria: 1.18-70 years old; 2.Has smear-positive pulmonary tuberculosis with initial laboratory results with resistance to rifampicin confirmed by GeneXpert; 3.Have an identifiable address and stay in the area during the study period. Exclusion Criteria: 1. Combined extrapulmonary tuberculosis; 2. HIV antibody positive and AIDS patients; 3. Critically ill patients, and according to the judgment of the research physician, it is impossible to survive for more than 4 months. Termination/termination criteria: 1. The patient requests to withdraw from the visit; 2. Misdiagnosis and error. The close contacts: Inclusion Criteria: 1. Willing to participate in trial treatment and follow-up and can give informed consent; 2. Willing to carry out HIV testing; 3. More than 6 hours of cohabitation per week in the 2 weeks prior to diagnosis of the index case. Exclusion Criteria: 1. Patients with active tuberculosis confirmed clinically or etiologically; 2. Mental illness and severe neurosis; 3. The researchers determined that there were any ineligible conditions. Termination/termination criteria: 1. The patient requests to withdraw from the visit; 2. Find a violation of inclusion or exclusion criteria during treatment.