Expanded Access Program With Pevonedistat (Given With Azacitidine) for Adults With Higher-risk Myelodysplastic Syndromes

Inclusion Criteria: 1. Has morphologically confirmed diagnosis of MDS. 2. With MDS have one of the following Prognostic Risk Categories, based on the Revised International Prognostic Scoring System (IPSS-R) * Very high (greater than \[\>\] 6 points). * High (\>4.5-6 points). * Intermediate (\>3-4.5 points): a participant determined to be in the Intermediate Prognostic Risk Category is only allowable in the setting of greater than or equal to (\>=) 5 percent (%) bone marrow myeloblasts. 3. Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1, or 2. 4. Has never been treated with Azacitidine, or, has been treated with Azacitidine, two or fewer cycles of Azacitidine have been administered, and has not relapsed while being treated with Azacitidine or failed Azacitidine treatment. Exclusion Criteria: 1. Has previous treatment for HR MDS with chemotherapy or other antineoplastic agents including hypomethylating agent (HMAs) such as decitabine or more than two cycles of azacitidine. • Previous treatment with lenalidomide is permitted, except that lenalidomide may not be given within 8 weeks of first dose of drug. 2. Has acute promyelocytic leukemia as diagnosed by morphologic examination of bone marrow, by fluorescent in situ hybridization or cytogenetics of peripheral blood or bone marrow, or by other accepted analysis. 3. Has either clinical evidence of or history of central nervous system involvement by acute myelogenous leukemia (AML). 4. Active uncontrolled infection or severe infectious disease, such as severe pneumonia, meningitis, or septicemia. 5. Has prothrombin time (PT) or activated partial thromboplastin time (aPTT) \>1.5\*upper limit of normal (ULN) or active uncontrolled coagulopathy or bleeding disorder. Participants therapeutically anticoagulated with warfarin, direct thrombin inhibitors, direct factor Xa inhibitors, or heparin are excluded from enrollment. 6. Has known hepatitis B surface antigen seropositivity, or known or suspected active hepatitis C infection. Note: Participants who have isolated positive hepatitis B core antibody (that is, in the setting of negative hepatitis B surface antigen and negative hepatitis B surface antibody) must have an undetectable hepatitis B viral load. Participants who have positive hepatitis C antibody may be included if they have an undetectable hepatitis C viral load. 7. Has known hepatic cirrhosis or severe preexisting hepatic impairment. 8. Has known cardiopulmonary disease defined as unstable angina, clinically significant arrhythmia, congestive heart failure (New York Heart Association Class III or IV), and/or myocardial infarction within 6 months before first dose, or severe pulmonary hypertension. 9. Has treatment with strong cytochrome P 3A (CYP3A) inducers within 14 days before the first dose of pevonedistat. .