This study evaluates the prognostic value and potential therapeutic impact of combined pressure and flow measurements in the evaluation of epicardial coronary stenosis and microvascular function.
ILIAS registry is a global effort to gather lesion-level data on the diagnostic and prognostic value of combined coronary pressure and flow measurements in clinical practice. Data is gathered from 7 nations (The Netherlands, Korea, Japan, Spain, Italy, Denmark, USA), using either coronary Doppler velocity measurements or coronary thermodilution measurements to obtain invasive coronary flow assessment. Patient treatment was governed by the local clinical practice guidelines at the time of the invasive procedure, but was at the operator's discretion. A standardized data collection sheet was used and all study adopted standardized definition of patient's baseline characteristics, clinical outcomes, and physiologic data. In case of acute coronary syndrome (unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction), only non-culprit vessel evaluation was used.
Study Type
OBSERVATIONAL
Enrollment
2,322
Calculation of the resting mean distal coronary to aortic pressure ratio (resting Pd/Pa), fractional flow reserve (Pd/Pa at hyperemia), Coronary flow reserve (peak flow/resting flow), microvascular resistance (Pd/flow).
Cincinnati University Medical Center
Cincinnati, Ohio, United States
Aarhus University Hospital
Aarhus, Denmark
Catholic University of the Sacred Heart
Roma, Italy
Major adverse cardiac events
Cumulative incidence of a composite of any death, any myocardial infarction, or any ischemia-driven revascularization
Time frame: 10 years
Target vessel failure
Cumulative incidence of a composite of cardiac death, target-vessel related myocardial infarction, or target-vessel revascularization
Time frame: 10 years
Individual components of MACE and TVF
Cumulative incidence of the individual components of MACE and TVF
Time frame: 10 years
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Gifu Heart Center
Gifu, Japan
Toda Central General Hospital
Toda, Japan
Tsuchiura Kyodo General Hospital
Tsuchiura, Japan
Amsterdam UMC - location AMC
Amsterdam, Netherlands
Tergooi
Blaricum, Netherlands
Amphia Hospital
Breda, Netherlands
Samsung Medical Center
Seoul, South Korea
...and 2 more locations