A Prospective cohort study including couples with poor responder females who undergoing ICSI
Purpose: To determine the optimal embryonic stage for transfer in poor responders. Method: Patients were divided into day 3 transfer group and day 5 transfer group. All cases had the same stimulation protocol and planning to do fresh embryo transfer. Assessments will be at Day 1, Day 3 and Day 5/6 according to Gardner's criteria 1999. Embryological and clinical data were recorded and then analyzed using SPSS (version 23) statistical software.
Study Type
OBSERVATIONAL
Enrollment
300
transferring embryos through ICSI procedures for poor responders on cleavage stage of embryonic development.
transferring embryos through ICSI procedures for poor responders on blast stage of embryonic development.
Ganin fertility center
Cairo, Egypt
RECRUITINGLive birth rate
percentage of cycles started with the intent of egg retrieval that led to a live birth.
Time frame: delivery of healthy neonate after 37 weeks of pregnancy
Implantation rate
Percentage of the implanted embryos number for each group / number of transferred embryos.
Time frame: 6 weeks of pregnancy
Clinical pregnancy rate
Percentage of pregnant cases with fetal heart / transferred cases for each group
Time frame: after 6 weeks of embryonic transfer
Cancellation rate
percentage of blast transfer cases who did not achieve blast stage (cancelled cases) / total number of blast stage cases
Time frame: 5:6 days of ICSI
Fertilization rate
Percentage of fertilized oocyte (appearance of two pronuclei) / Number of injected oocytes
Time frame: 16:19 hours after intracytoplasmic injection(ICSI)
Cleavage rate
Percentage of cleaved embryos / Number of fertilized oocytes
Time frame: 72 hours after ICSI
High quality day 3 embryos
High quality D3 embryos according to Gardner's criteria / total cleaved embryos
Time frame: 72 hours after ICSI
Blast rate
Percentage of total blastocysts / Total cleaved embryos
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 5:6 days of ICSI
High quality blast rate
Morphological grading of trophectoderm and Inner cell mass using Gardner's criteria 1999, from grade A and B ( A is the highest quality). Total high grade embryos/ total blast embryos.
Time frame: 5:6 days of ICSI