The purpose of this randomized cross-over clinical trial is to examine the effects of Mediterranean diet based intervention on inflammation, metabolic risk and microbiome in patients with dyslipidemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
100
Diet instruction and menu samples from the dietitian on following the Mediterranean Diet.
Gangnam Severance Hospital
Seoul, South Korea
RECRUITINGChange in body weight
body weight (kg)
Time frame: baseline, 4 weeks, 10 weeks
Change in fat mass
fat mass (kg) measured by bioelectrical impedance analyzer
Time frame: baseline, 4 weeks, 10 weeks
Change in muscle mass
muscle mass (kg) measured by bioelectrical impedance analyzer
Time frame: baseline, 4 weeks, 10 weeks
Change in leukocyte count
leukocyte count (/μL)
Time frame: baseline, 4 weeks, 10 weeks
Change in C-reactive protein
C-reactive protein (mg/L)
Time frame: baseline, 4 weeks, 10 weeks
Change in fasting glucose
fasting glucose (mg/dL)
Time frame: baseline, 4 weeks, 10 weeks
Change in insulin
insulin (mcIU/mL)
Time frame: baseline, 4 weeks, 10 weeks
Change in triglyceride
triglyceride (mg/dL)
Time frame: baseline, 4 weeks, 10 weeks
Change in high-density lipoprotein cholesterol (HDL-cholesterol)
HDL-cholesterol (mg/dL)
Time frame: baseline, 4 weeks, 10 weeks
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Change in low-density lipoprotein cholesterol (LDL-cholesterol)
LDL-cholesterol (mg/dL)
Time frame: baseline, 4 weeks, 10 weeks
Change in gut microbiome
Gut microbiome
Time frame: baseline, 4 weeks, 10 weeks
Change in metabolomic response
metabolomic profile of lipid metabolism
Time frame: baseline, 4 weeks, 10 weeks