The Effect of Coffee Consumption on the Serum Levels of Leptin, Folic Acid, and Vitamin B12

Applied Science Private University120 enrolled

Overview

The effect of coffee and body weight during the last 3 months on the level of leptin, folic acid, and vitamin B12

Coffee consumption has been associated with several risk factors leading to cardiovascular diseases (CVDs), including hyperhomocysteinemia and hyperlipidemia. Frequent coffee consumption has beneficial effects in reducing the risk of diabetes mellitus (DM) type 2, obesity, liver disease, CVDs, some types of cancer, Parkinson's disease, and Alzheimer's disease. Controversies concerning coffee consumption benefits and risks in regards for CVDs were mentioned in many studies. Folic acid and vitamin B12 are necessary vitamins in homocysteine metabolism which is a risk factor for atherosclerosis. Leptin, is a hormone linked to obesity and it could be related to atherosclerosis. The combined effect of coffee consumption and body weight on the levels of leptin, folic aid, and vitamin B12 is not well studied. In our study, we will study the effect of coffee consumption in males with different body mass indices to see the effect of several important parameters such as leptin, Folic acid, and vitamin B12.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Atherosclerosis

Interventions

Normal BMI and moderate coffee consumptionBEHAVIORAL

Normal BMI and moderate coffee consumption

Normal BMI and heavy coffee consumptionBEHAVIORAL

Normal BMI and heavy coffee consumption

overweight and moderate coffee consumptionBEHAVIORAL

overweight and moderate coffee consumption

Eligibility

Sex: MALEMin age: 18 YearsMax age: 26 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male, * ASU student, * do not have any acute or chronic medical conditions. Exclusion Criteria: * students who used any medications for either an acute and/or a chronic condition during the past 3 months prior to the study entry.

Locations (1)

Applied Science University

Amman, Jordan

Outcomes

Primary Outcomes

leptin

Plasma Concentration of leptin in ng /ml

Time frame: Baseline

folic acid

Plasma Concentration of folic acid in ng /ml

Time frame: Baseline

Vitamin B12

Plasma Concentration of Vitamin B12 in pg /ml

Time frame: Baseline

Secondary Outcomes

fasting blood glucose

Plasma Concentration of glucose mg/dL

Time frame: Baseline

lipid profile

Plasma Concentration of LDL, HDL in mg/dl

Time frame: Baseline

Data from ClinicalTrials.gov

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