The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly

Shenzhen Second People's Hospital350 enrolled

Overview

Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery. Different anesthesia methods have different incidences of PND, but it's still unknow which is better between spinal anesthesia and nerve block combined with general anesthesia. We will apply a psychometric battery test which contain different cognitive domains to estimate the incidence of PND at a week a month and a year after surgery with different anesthesia methods. Study has showed that functional magnetic resonance imaging (fMRI) could detect a cognitive decline through spontaneous neuronal activity in the cortex and hippocampus. In our study, multi-mode imaging technology is used to conduct in-depth research on MRI and make correlation analysis with cognitive function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

350

Conditions

PND

Interventions

Patients in this group receive nerve block combined with general anesthesia.

spinal anesthesiaDEVICE

Patients in this group receive spinal anesthesia.

Eligibility

Sex: ALLMin age: 60 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * aged 60-85years * ASA I-III * Received elective surgery of unilateral lower extremity orthopedics * The anesthesia lasted more than 2 hours Exclusion Criteria: \-

Locations (1)

Shenzhen Second People's Hospital

Shenzhen, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

Incidence of PND seven days after surgery

Time frame: seven days after surgery

Secondary Outcomes

Incidence of PND one month after surgery

Time frame: one month after surgery

Incidence of PND one year after surgery

Time frame: one year after surgery

Hospital stay

Time frame: one to two weeks after surgery

Number of patients entrance the ward of ICU after surgery

Time frame: one week post-operation

Mortality rate

Time frame: one year after surgery

Postoperative complications

Time frame: one month post-operation

ADL of frontal lobe，temporal lobe and occipital lobe