The purpose of this study is to determine the effect of a dietary supplement rich in nitric oxide (NO) on nasal nitric oxide and fractional exhaled nitric oxide (FeNO),on ciliary beat frequency assessed by high-speed digital video microscopy and on lung function assessed by spirometry in normal patients and patients with Primary ciliary dyskinesia (PCD).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Patients will ingest 1 bottle (70ml) of beet-it juice (98% concentrated beet juice, 2% lemon juice containing 400 mg/6.5 mmol nitrate).
The University of Texas Health Science Center at Houston
Houston, Texas, United States
RECRUITINGChange in nasal NO as measured by a chemiluminescence analyzer
Time frame: Baseline,after beet juice consumption(1 hour after consumption)
Change in nasal NO as measured by a chemiluminescence analyzer
Time frame: Baseline,after beet juice consumption( 2 hours after consumption)
Change in nasal FeNO as measured by using the NIOX MINO® Airway Inflammation Monitor
Time frame: Baseline,after beet juice consumption(1 hour after consumption)
Change in nasal FeNO as measured by using the NIOX MINO® Airway Inflammation Monitor
Time frame: Baseline,after beet juice consumption(2 hours after consumption)
Change in ciliary beat frequency as measured using high-speed video-microscopy (HSVM)
Time frame: after beet juice consumption(2 hours after consumption)
Change in lung function as measured by spirometry
spirometry is used to assess how well your lungs work by measuring how much air you inhale,how much you exhale and how quickly you exhale
Time frame: Baseline,after beet juice consumption(2 hours after consumption)
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