The Efficacy and Safety of a Latest Dural Substitute

Inclusion Criteria: * Any patient between the ages of 18 and 75 years scheduled for elective cranial surgery involving a dural incision. * Dural defects and surgical incision was classifed as level 1 Exclusion Criteria: * local or systemic infection. * patients with known allergy to Equipment components * a history of traumatic head injury * a compromised immune system or autoimmune disease * patients who should not participate based on the surgeon's opinion * patients participating in any other drug or device trial. * expected survival time \<12 months * underwent chemoradiotherapy 3 months before randomization * uncontrolled diabetes and malignant tumor * women who were pregnant, lactating, or wished to become pregnant during the study;