This study will compare the clinical outcome of patients with maintenance dialysis room after changing the iron treatment guidelines from original upper limit with ferritin\>500ng/ml, or TSAT\>20% to Ferritin\> 800ng / ml, or TSAT\> 50%.
After two years of treatments, we will compare the incidence of clinical events, monthly blood, and biochemical examination data for the two years before and after the change.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
200
drug ingredient: Ferric Hydroxide in complex with sucrose drug dosage form: 270injection/100mg/5ml/Amp
Kaohsiung Medical University Hospital
Kaohsiung City, Taiwan
RECRUITINGMortality
the death events following up until 2022
Time frame: 2 years
coronary artery disease
new onset coronary artery disease diagnosed with electrocardiogram (ST-segment changes, T inversion and Q wave appearance)
Time frame: 2 years
coronary artery disease
Progression of coronary artery disease (SCCT grading increase : 0% = no visible stenosis, 1-24% = minimal stenosis, 25-49% = mild stenosis, 50-69% = moderate stenosis, 70-99% = severe stenosis, 100% = occlusion)
Time frame: 2 years
coronary artery disease
new onset coronary artery disease diagnosed with cardiac enzyme (\>troponins I upper limit 99%)
Time frame: 2 years
congestive heart failure
new onset congestive heart failure diagnosed with sonocardiogram (HF-REF, heart failure with reduced EF≦ 35%)
Time frame: 2 years
congestive heart failure
Progression of congestive heart failure (increase of NYHA classification)
Time frame: 2 years
congestive heart failure
new onset congestive heart failure with symptoms (Framingham's clinical criteria: orthopnea, pulmonary rales, S3, paroxysmal nocturnal dyspnea, cough, dyspnea on ordinary exertion, pleural effusion, hepatomegaly, tachycardia with a heart rate over 120 beats/min, bilateral leg edema, and weight loss under 4.5 kg in five days) diagnosed by cardiologists
Time frame: 2 years
congestive heart failure
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new onset congestive heart failure (brain natriuretic peptide\> 400pg/ml)
Time frame: 2 yearts
diabetes
fasting blood sugar
Time frame: 2 years
diabetes
postprandial blood sugar
Time frame: 2 years
diabetes
glycated hemoglobin
Time frame: 2 years
anemia
1. serum hemoglobin level 2. serum hematocrit
Time frame: 2 years
calcium
serum total calcium level
Time frame: 2 years
phospate
serum phosphate level
Time frame: 2 years
nutrition status
serum albumin level
Time frame: 2 years
liver function
serum AST/ALT level
Time frame: 2 years
liver function
abdominal sonography with Child classification of liver cirrhosis
Time frame: 2 years
sodium
serum sodium level
Time frame: 2 years
potassium
serum potassium level
Time frame: 2 years
parathyroid function
serum parathyroid level
Time frame: 2 years