To Evaluate the Safety, Tolerability, and Pharmacokinetics Profiles of TG-1000 in Healthy Volunteers, and the Food Effect on Pharmacokinetics of Single Oral Dose of TG-1000 in Healthy Volunteers.

Inclusion Criteria: 1. Willing to provide written informed consent. 2. Age 18 (or legal adult age) to 45 years. 3. Body mass index (BMI) in the range of ≥19.0 to ≤ 24.0 kg/m2 and body weight ≥ 50 kg for male and ≥ 45 kg for female at Screening. 4. Subjects have good communication with Investigator and agree to follow the study requirement to complete study. Exclusion Criteria: 1. Clinically significant abnormality in 12-lead ECG, chest X-ray, abdominal ultrasounds, physical examination, vital signs or laboratory values at Screening or Day-1. 2. Positive breath alcohol or urine drug tests at Day-1. 3. Positive test results for Immunoglobulin M anti-HAV antibody, HBsAg, anti-HCV antibody, HIV or syphilis at Screening. 4. Female subjects with positive pregnancy test results at Screening or Day-1. 5. Male subjects are unwilling to use effective contraception and refrain from sperm donation from Screening until 3 months after the study drug administration. 6. Current or prior history of any of the following: 1. Significant cardiac disease, diabetes, liver, kidney disease, psychiatric diseases or drug abuse or diseases that will affect immunity. 2. Difficulty in swallow or gastrointestinal disorder that could interfere with the absorption of the study drug 3. Difficulty in blood sampling or venipuncture 4. Drug allergy or hypersensitivity 5. Blood donation ≥ 400 mL within 3 months before and after study. 6. Alcoholics or frequent drinkers prior to Screening. 7. Frequent smokers prior to Screening. 7. Use of any prohibited medications or surgeries prior to study drug administration: a. Received any other investigational agents or devices, liver enzyme inducer or inhibitors, medications including prescriptions, non-prescriptions or herbal remedies, dietary supplements or surgeries. 8. Unwilling to abstain from alcohol, tobacco, nicotine containing products, caffeine- or xanthine-containing beverages from Screening until discharge from the phase I unit. 9. Subjects may not be qualified for the study judged by the Investigator.