The proposed study is a single-blind randomized controlled trial which seeks to characterize implantation rates following embryo vitrification and subsequent warming with both slush nitrogen and liquid nitrogen. After warming, implantation rates and pregnancy outcomes will be assessed.
The purpose of this study is to determine if slush nitrogen for embryo vitrification results in higher sustained implantation rates compared to the conventional use of liquid nitrogen. Routine ovarian stimulation, oocyte retrieval and embryology care will ensue. All blastocyst stage embryos will be randomized to either the control (liquid nitrogen) or intervention group (slush nitrogen) and vitrified after trophectoderm biopsy has been performed for PGT-A (preimplantation genetic testing for aneuploidy). A single, chromosomally normal embryo will be transferred in a subsequent frozen embryo transfer cycle per routine. Implantation rates and pregnancy outcomes will be assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
253
blastocyst stage embryos will be vitrified via slush nitrogen
Reproductive Medicine Assoicates of New Jersey
Basking Ridge, New Jersey, United States
sustained implantation rate
fetal heart beat present upon discharge at 8 weeks
Time frame: approximately 8 weeks gestation age
clinical pregnancy rate
presence of gestational sac in uterus
Time frame: usually by 5 weeks gestational age
miscarriage rate
pregnancy loss
Time frame: 1-8 months dependent on gestational age of loss
live birth rate
delivery of live infant
Time frame: 9 months
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