Sex-Informed Data in the COVID-19 Pandemic.

University of Roma La Sapienza88 enrolled

Overview

Sex and gender matter to health equity, especially in a pandemic. Sex (a biological attribute) and gender (a social construct) may influence an individual's susceptibility, vulnerability and exposure to infectious disease. In previous coronavirus epidemics (SARS and MERS), male sex was associated with worse outcomes. Both immune and the hemostatic response display ample sexual dimorphism. The primary aim of the study is to determine whether sex differences in biomarkers of platelet and immune function, gut microbiome, clinical characteristics, therapy, clinical cost sensitive outcomes (i.e. in-hospital transition of care, case severity, and mortality due to COVID-19) exist in patients affected by COVID-19.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Covid19

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with laboratory confirmed SARS-Cov-2 infection of any severity. Exclusion Criteria: * Pregnancy. * Younger than 18 years of age.

Locations (1)

Sapienza University of Rome - Policlinico Umberto I Roma

Rome, Italy

Outcomes

Primary Outcomes

Sex differences in platelet and immune function and COVID19 severity

Sex differences in biomarkers of platelet and immune function correlate with severity of disease

Time frame: 3 months

Secondary Outcomes

Gut microbiome and COVID19 severity

Differences in the gut microbiome correlate with severity of disease