The purpose of study is to assess the effectiveness of nebulized magnesium sulphate in children presenting with acute asthma.Study perfoma consists of demographic variables,exclusion criteria and pediatric asthma score that includes respiratory rate,SPO2 at room air(requirement of oxygen),auscultatory findings in chest,dysnea and retractions.
After getting informed consent from guardian,148 patients of acute moderate ro severe asthma with pediatric asthma score 8-15 will be randomly classified into 2 groups and one group will receive nebulization with magnesium sulphate and other will receive intravenous magnesium sulphate and effectiveness will be compared by 4 point reduction in PAS from baseline in either groups after 6 hours.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
148
MgSO4 100mg in 20 ml normal saline will be given via ultrasonic nebulizer over 10 minutes,and PAS score will be assessed at 30,60,120,240,360 minutes
pts age 2 to 12 years will receive intravenous magnesium sulphate 50 mg/kg over half hour
King edward medical university/mayo hospital lahore
Lahore, Punjab Province, Pakistan
Efficacy of nebulized magnesium sulphate with intravenous magnesium sulphate in children with acute asthma will be assessed by a drop in PAS score, as assessed at 6 hours of intervention.
The intervention will be considered effective if there is a drop of at least 4 points in PAS score at hour-6 of intervention.
Time frame: 6 hours
duration of ICU stay
this will be measured in hours
Time frame: 72 hours/3 days
duration of hospital stay
this will be measured in hours
Time frame: 120 hours/5 days
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