Creatine Supplementation in Autism Spectrum Disorder

University of Novi Sad, Faculty of Sport and Physical Education20 enrolled

Overview

Autism Spectrum Disorder (ASD) is accompanied by reduced levels of total creatine in right temporal-parietal junction and other brain regions of interest, and addressing this deficit by exogenous administration of creatine may have beneficial effects on brain metabolism and disease-specific clinical symptoms in patients suffering from ASD.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Autism Spectrum Disorder

Interventions

CreatineDIETARY_SUPPLEMENT

Creatine monohydrate (20 g per day)

Eligibility

Sex: ALLMin age: 10 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 10 years and above * Informed consent signed by a parent or legal guardian or legal representative * Diagnostic and Statistical Manual of Mental Disorders-IV criteria for ASD. Exclusion Criteria: * Pregnant or nursing female patients * Non-pharmacologic therapy * Current diagnosis of other mental disorder

Locations (1)

FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, Serbia

Outcomes

Primary Outcomes

Brain creatine change

Monitor change in brain creatine levels by magnetic resonance imaging

Time frame: Change from Baseline Brain Creatine Levels at 6 Months

Secondary Outcomes

Brain N-acetylaspartate change

Monitor change in brain N-acetylaspartate levels by magnetic resonance imaging

Time frame: Change from Baseline Brain N-acetylaspartate Levels at 6 Months

Autism Treatment Evaluation Checklist (ATEC) score

Monitor changes in ASD severity

Time frame: Change from Baseline ATEC Scores at 6 Months

Data from ClinicalTrials.gov

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