The Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: a 2-centre Study

Yuanli Lei274 enrolled

Overview

The purpose of the present study was to investigate ECG findings of patients with acute myocarditis, ECG findings associated with fulminant myocarditis, and the characteristics of ST-elevation on admission.

Acute myocarditis is a severe disease with high mortality rate and various dynamic changes visible on electrocardiograms (ECGs). The aim were to investigate ECG findings in acute myocarditis, ECG findings associated with fulminant myocarditis (FM), and the characteristics of ST elevation at admission. A retrospective analysis of 1814 ECGs was conducted from 274 consecutive patients with acute myocarditis aged ≥13 years, who were hospitalized in two centres between August 2007 and November 2019. All ECG obtained during the hospital course were evaluated by 2 electrophysiologists. A chi-square test was used to evaluate and compare the abnormal ECG findings between the FM and non-FM groups, and multivariate logistic regression analysis was performed to further evaluate ECG findings associated with FM. The Mann-Whitney U test was used to compare the duration of cardiac symptoms before admission for ST elevation at admission.

Study Type

OBSERVATIONAL

Enrollment

274

Conditions

Myocarditis

Interventions

ECGDEVICE

12-lead ECG

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * clinical diagnosis of Acute myocarditis * complete data of ECG Exclusion Criteria : * Incomplete data; * a history of congenital heart disease, cardiomyopathy or arrhythmias; * myocarditis not being the primary diagnosis for a particular admission; * absence of cardiac symptoms.

Locations (1)

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China

Outcomes

Primary Outcomes

The percentage rate of ST elevation

ST elevation was the typical ECG changes of acute myocarditis. The study was to investigate how many patients presented with ST elevation on admission.

Time frame: through study completion, an average of 2 years

Secondary Outcomes

Atrioventricular block, ventricular tachycardia and their correlationwith Fulminant myocarditis (FM)

FM is a peculiar clinical condition and is an acute and severe form of myocarditis . FM is associated with a wide variety of ECG findings. The study was to investigate Atrioventricular block, ventricular tachycardia and their correlation with FM.

Time frame: through study completion, an average of 6 months

Data from ClinicalTrials.gov

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