MAP to Provide Access to Nilotinib, for Patients With HES

Inclusion criteria 1. ≥ 18 years of age 2. Hypereosinophilic syndrome/chronic eosinophilic leukemia who have a clinical indication for treatment and meet the following criteria (Vandenberghe, et al 2004): * eosinophilia greater than 1500/mm3 which persists greater than 6 months * exclusion of other causes of eosinophilia including clonal or abnormal T-cell populations, exclusion of reactive eosinophilia, and malignancies or T-cell disorders associated with eosinophilia * signs and symptoms of organ involvement 3. WHO Performance status of ≤ 2 4. Patient must have the following laboratory values: * Potassium ≥ LLN (lower limit of normal) or corrected to within normal limits with supplements prior to the first dose of AMN107 * Total calcium (corrected for serum albumin) ≥ LLN or correctable with supplements * Magnesium ≥ LLN or corrected to within normal limits with supplements prior to the first dose of AMN107 * Phosphorus ≥ LLN or correctable with supplements * ALT and AST ≤ 2.5 x ULN or ≤ 5.0 x ULN if considered due to tumor * Alkaline phosphatase ≤ 2.5 x ULN unless considered due to tumor * Serum bilirubin ≤ 1.5 x ULN * Serum creatinine ≤ 1.5 x ULN * Serum amylase ≤ 1.5 x ULN and serum lipase ≤ 1.5 x ULNWritten patient informed consent must be obtained prior to start of treatment. Written patient informed consent must be obtained prior to start of treatment. Exclusion criteria Patients eligible for this Treatment Plan must not meet any of the following criteria: 1. History of hypersensitivity to any drugs or metabolites of similar chemical classes as nilotinib. Any exclusionary sites of disease (e.g., brain metastases). 2. Impaired cardiac function 3. Patients who have undergone major surgery ≤ 2 weeks prior to Visit 1 or who have not recovered from side effects of such surgery 4. Known Cytopathologically confirmed CNS infiltration. 5. Use of therapeutic warfarin. 6. Acute or chronic liver or renal disease considered unrelated to tumor. 7. Treatment with any hematopoietic colony-stimulating growth factors ≤ 1 week prior to starting Nilotinib. Erythropoietin is allowed. 8. Patient who has not recovered from side effects of prior chemotherapy, immunotherapy, other investigational drugs, wide field radiotherapy, or major surgery. Patient who has received imatinib \< 5 days prior to AMN107 or has not recovered from side effects of therapy. Hydroxyurea is permitted during the first 28 days of treatment (up to 5 g/day) for a maximum of 7 days. 9. Patient with a history of another primary malignancy that is currently clinically significant or requires active intervention. 10. Known diagnosis of human immunodeficiency virus (HIV). 11. Known ongoing alcohol or drug abuse 12. Unwillingness or inability to comply with the treatment protocol including returning for scheduled visits 13. Participation in a prior investigational study within 30 days prior to enrollment or within 5-half lives of the investigational product, whichever is longer. 14. Pregnant or nursing (lactating) women,