The purpose of this study is to determine the incidence,development trajectory and risk factors of the main peripartum mental health problems as well as explore its adverse outcomes.
Peripartum mental health problems (such as anxiety and depression), affecting more than 20% of mothers, is one of the most common complications around childbirth and gradually have become global public health issues. However, little is known about the course of peripartum mental health problems and possible fluctuations, as well as related risk factors among Chinese women. In addition, there are no effective prediction and preventive strategies for postpartum depression. The Peripartum Mental Health Cohort Study in Guangzhou will collect the epidemiological, clinical information and biological specimens across pregnancy and childbirth to establish trajectory of peripartum mental health and identify the factors influencing the fluctuations and build a comprehensive prediction model of postpartum depression, as well as explore its adverse outcomes. This study would help to determine the timing of screening and target interventions to improve women's and their offspring's health.
Study Type
OBSERVATIONAL
Enrollment
3,000
Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, China
RECRUITINGChange of prevalence of maternal prenatal depression
Using Self-rating Depression Scale (SDS) to assess maternal depressive symptoms during pregnancy. SDS scores ≥53 is defined as prenatal depressive symptoms.
Time frame: before 20th gestational week, after 33th gestational week and prior to delivery
Change of prevalence of maternal postpartum depression in the first year after delivery
Using Edinburgh Postnatal Depression Scale (EPDS) to assess postpartum depressive symptoms. EPDS scores ≥13 is defined as postpartum depressive symptoms.
Time frame: 6 weeks, 6 months and 1 year after delivery
Change of prevalence of maternal anxiety during pregnancy
Using Self-rating Anxiety Scale (SAS) to assess maternal anxiety during pregnancy. SAS scores ≥50 is defined as anxiety.
Time frame: before 20th gestational week, after 33th gestational week and prior to delivery
Level of maternal cortisol during pregnancy
Using women's blood samples to test the concentration of cortisol.
Time frame: During period of 2-3 trimesters of pregnancy
Levels of maternal inflammatory factors during pregnancy
Using women's blood samples to test the concentration of inflammatory factors, including CRP, IL-6, TNF-α, etc.
Time frame: During period of 2-3 trimesters of pregnancy
Prevalence of preterm birth, small for gestational age, low birth weight
Obtained from electronic medical records.
Time frame: At delivery
Child's neurodevelopment at early childhood
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Assessed by using the Gesell Developmental Schedules, which includes adaptive, gross motor, fine motor, language, and social function domains. Higher score in each domain is considered a better outcome, while no more than 85 is defined as suspected development delay.
Time frame: At child's age of 1 year