Ondansetron and Blood Coagulation

Seoul National University Bundang Hospital12 enrolled

Overview

Ondansetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of ondansetron. The investigators therefore will perform the present study to measure the effect of ondansestron on the blood coagulation pathway according to the drug concentration level using a thromboelastography test.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Blood Coagulation Disorder

Interventions

0 ul of ondansetronDRUG

Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 nl) using ondansetron

0.2 ul of ondansetronDRUG

Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.2 ul) using ondansetron

2 ul of ondansetronDRUG

Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (2 ul) using ondansetron

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy vonlunteers * Age: 20 to 65 years * Body weight \> 50 kg * Volunteers who provided informed consent Exclusion Criteria: * Hematologic disease * Anticoagulant medication

Locations (1)

Seoul National Univ. Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

RECRUITING