The function of the autonomic nervous system can be assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV). Decreased HRV has been shown to be predictive of morbidity and mortality in diverse medical conditions such as acute myocardial infarction, aneurysmal subarachnoid haemorrhage, autoimmune diseases, sepsis and surgery. The function of the autonomic nervous system has not yet been investigated in a "pure hypovolemia" model. The aim of the current study is therefore to investigate and describe the function of the autonomic nervous system prior to, during and after reduction of blood volume in healthy blood donors.
Study Type
OBSERVATIONAL
Enrollment
25
Monitoring of the autonomic nervous system using E-patch, LiDCO and Root-Massimo.
Hvidovre University Hospital
Copenhagen, Denmark
Changes in root mean square of successive NN-interval differences (RMSSD) during mobilisation
Measured in ms
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in root mean square of successive NN-interval differences (RMSSD) during sleep
Measured in ms
Time frame: The night before and night after blood donation
Changes in standard deviation of N-N intervals (SDNN) during mobilisation
Measured in ms
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in standard deviation of N-N intervals (SDNN) during sleep
Measured in ms
Time frame: The night before and night after blood donation
Percentage of successive RR intervals that differ by more than 50 ms (pNN50) during mobilisation
Measured in %
Time frame: 15 minutes prior to and 15 minutes after blood donation
Percentage of successive RR intervals that differ by more than 50 ms (pNN50) during sleep
Measured in %
Time frame: The night before and night after blood donation
Changes in low frequency (LF) power during mobilisation
Measured in ms\^2
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in low frequency (LF) power during sleep
Measured in ms\^2
Time frame: The night before and night after blood donation
Changes high frequency (HF) power during mobilisation
Measured in ms\^2
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes high frequency (HF) power during sleep
Measured in ms\^2
Time frame: The night before and night after blood donation
Changes in ratio of LF-to-HF power during mobilisation
Measured in %
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in ratio of LF-to-HF power during sleep
Measured in %
Time frame: The night before and night after blood donation
Changes in S (area of the ellipse which represents total HRV) during mobilisation
Measured in ms
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in S (area of the ellipse which represents total HRV) during sleep
Measured in ms
Time frame: The night before and night after blood donation
Changes in SD1 (Poincaré plot standard deviation perpendicular the line of identity) during mobilisation
Measured in ms
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in SD1 (Poincaré plot standard deviation perpendicular the line of identity) during sleep
Measured in ms
Time frame: The night before and night after blood donation
Changes in SD2 (Poincaré plot standard deviation along the line of identity) during mobilisation
Measured in ms
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in SD2 (Poincaré plot standard deviation along the line of identity) during sleep
Measured in ms
Time frame: The night before and night after blood donation
Changes in SD1/SD2 ratio during mobilisation
Measured in ms
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in SD1/SD2 ratio during sleep
Measured in ms
Time frame: The night before and night after blood donation
Changes in systolic arterial pressure (SAP) during mobilization
Measured in mmHg by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in diastolic arterial pressure (DAP) during mobilization
Measured in mmHg by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in mean arterial pressure (MAP) during mobilization
Measured in mmHg by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in pulse pressure (PP) during mobilization
Measured in mmHg by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in heart rate (HR) during mobilisation
Measured in beats min-1 by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in cardiac output (CO) during mobilization
Measured in L/min by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in stroke volume (SV) during mobilization
Measured in mL by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in systemic vascular resistance (SVR) during mobilization
Measured in dynes s cm-5 by non-invasive LiDCO
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in cerebral perfusion (ScO2) during mobilization
Measured in % by Root Masimo
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in muscular perfusion (SmO2) during mobilization
Measured in % by Root Masimo
Time frame: 15 minutes prior to and 15 minutes after blood donation
Changes in peripheral index during mobilization
Measured in % by Root Masimo
Time frame: 15 minutes prior to and 15 minutes after blood donation
Concentration of C-reacitve protein
Measured in gr/dL
Time frame: At time of blood donation
V-PLEX Biomarker 54.Plex Kit
54 key analytes that are important in inflammation response and immune system regulation as well as numerous other biological processes
Time frame: Blood taken at time of blood donation
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