This study compares the success rate of Adjuvant isonicotinic acid hydrazide and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
In the past, the role of laminaria and prostaglandins in cervical dilatation and reducing intraoperative complications of cervical dilatation have been proven . Misoprostol is a synthetic analogue of prostaglandin E1 used to treat and prevent gastric ulcers, which is now widely used in obstetrics and gynecology. Its applications in obstetrics and gynecology include medical abortion in the first and second trimesters of pregnancy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
240
Drug: Isonicotinic Acid then misoprostol Drug: Isonicotinic Acid 300mg total dose 900 mg per day for 3 days
Drug: placebo then misoprostol Drug: Placebo placebo for 3 days
Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion
Aswan University Hospital
Aswān, Egypt
induction to abortion time
induction to abortion time
Time frame: 9 hours
number of patient with complete abortion
number of patient with complete abortion
Time frame: 9 hours
number of patient need for surgical evacuation of the products of conception
number of patient need for surgical evacuation of the products of conception
Time frame: 12 hours
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