This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.
The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
562
Propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia
Sevoflurane or desflurane for induction and maintenance of anesthesia
Seoul National University Hospital
Seoul, South Korea
five year metastasis-free survival
five year metastasis-free survival
Time frame: five year after surgery
one year survival
survival rate regardless of recurrence
Time frame: one year after surgery
three year survival
survival rate regardless of recurrence
Time frame: three year after surgery
one year metastasis-free survival
one year metastasis-free survival
Time frame: one years after surgery
three year metastasis-free survival
three year metastasis-free survival
Time frame: three years after surgery
five year survival
survival rate regardless of recurrence
Time frame: five year after surgery
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