The effect of transauricular electrical vagal nerve stimulation (taVNS) will be studied on temporal summation of heat pain (TSP) in 30 patients with chronic low-back pain and in 30 heathy volunteers. Participants will receive either taVNS or sham stimulation before and during TSP induction in a randomized crossover manner. The participants will be unaware regarding the type of intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
60
transauricular electrical vagal nerve stimulation will be applied to the cymba conchae of both ears using ECO2 TENS device (manufactured by Schwa-Medico GmbH/Germany) with currency intensity of max 10 mA and current frequency 2/100 Hz.
ECO2 TENS device (manufactured by Schwa-Medico GmbH/Germany)
University Medicine of Greifswald
Greifswald, Germany
RECRUITINGUnpleasantness of pain
Perceived unpleasantness of pain, which participants will rate continuously during the repetitive heat stimulation using a computerized visual analogue scale (CoVAS, Medoc Advanced Medical Systems, Ramat Yishai, Israel) ranging from 0 (= not unpleasant at all) to 100 (= intolerable pain)
Time frame: Continuously 5 minutes during the experimental heat pain stimulation
Heart rate
Heart rate (bpm)
Time frame: 10 minutes (before, during and after stimulation of heat pain)
blood pressure
non-invasive measurement of systolic and diastolic blood pressure
Time frame: 10 minutes (before, during and after stimulation of heat pain)
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