Role of Famotidine in the Clinical Improvement of COVID-19 Patients.

Chattogram General Hospital208 enrolled

Overview

This study is aimed to investigate the effect of Famotidine in the clinical recovery of COVID-19 patients. COVID19 is a worldwide pandemic. Hence SARS-CoV-2 is a novel virus; there is no specific medication against it. Like other countries of the world, Besides antiviral drugs, immunosuppressive agents, and symptomatic therapy like H2 receptor blocker FAMOTIDINE came to the limelight due to its role in reducing the symptoms of COVID-19 patients. The study will include COVID-19 participants to confirm by RT PCR or an HRCT chest. Detail history of each participant with comorbidity will be taken and will be examined carefully. The hospitalized patients admitted to the HDU/ICU units will be enrolled in this study. Critically ill patients who require ventilator support will not be included in this study. The outcome of the Famotidine treatment will be evaluated and compared with a control group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

208

Conditions

Covid19

Interventions

Eligibility

Sex: ALLMin age: 16 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * SARS-CoV-2 infection confirmed by RT PCR or CT Chest. * Severe COVID-19 patients require hospitalization under HDU/ICU. Exclusion Criteria: * Patients with severe and/or uncontrolled medical conditions with significantly compromised organ function. * Patients who were hospitalized from the before due to other reasons. * Contraindication / possible drug interaction with Famotidine with existing therapy. * Immunocompromised patients. * Pregnancy, Pulmonary Tuberculosis, AIDS

Outcomes

Primary Outcomes

Time to Clinical Improvement (TTCI)

Time to clinical improvement (TTCI) was defined as time from randomization to National Early Warning Score 2 (NEWS2) Score of ≤2 maintained for 24 Hours.

Time frame: Following randomization 30days.

Time to symptomatic recovery.

Time to Symptomatic recovery was defined as the duration (in days) that required for the relief of the COVID-19 symptoms from the day of hospitalization.