Rosuvastatin Evaluation as a Tuberculosis Treatment Adjunct

Inclusion Criteria: 1. Aged 18 - 75 years of age 2. Abnormalities on CXR compatible with pulmonary TB 3. At least one sputum specimen, produced at or prior to screening during the current illness episode, that is: (i) positive for acid-fast bacilli on smear microscopy (with at least 1+ on the IUATLD/WHO scale) and/or (ii) positive on testing by Xpert MTB/RIF or Xpert Ultra (with semi-quantitative cycle threshold (CT) result of 'medium' or 'high') 4. Able to produce at least 5ml of sputum per day at the time of screening 5. Current or planned treatment with a regimen containing rifampicin, isoniazid and pyrazinamide (with or without ethambutol) only 6. Resident at a fixed address within feasible travelling distance to the site and likely to remain a local resident for the duration of trial follow-up 7. Willing to have directly observed therapy (DOT) 8. Willing to comply with the study visits and procedures Exclusion Criteria: 1. More than 7 days of standard TB treatment by the time of the baseline visit 2. Known rifampicin resistance or isoniazid resistance at the time of randomization (results by conventional DST or molecular tests are not required to be available prior to randomization) 3. Previous treatment for active TB disease, unless rifampicin susceptibility has been demonstrated on a molecular test performed during this episode. 4. Extrapulmonary TB that, in the opinion of the treating clinician, is likely to require concurrent use of steroids, or require surgical management. 5. Known hypersensitivity to rosuvastatin 6. History of myopathy or family history of hereditary muscular disorders 7. Acute liver failure or decompensated chronic liver disease 8. Current alcohol abuse 9. Known hypothyroidism 10. Any of the following laboratory parameters at screening: 1. ALT \>3 times upper limit of normal (ULN) 2. Estimated glomerular filtration rate (eGFR) \< 60ml/min/1.73m2 (calculated using the CKD-EPI equation) (81) 3. Creatine Kinase \>5 times ULN 4. Potassium \<2.5 mmol/L 11. Active malignancy on chemotherapy or radiotherapy 12. Current use of immunosuppressive medication (≤ 5mg/ day of prednisolone or equivalent is acceptable). 13. HIV infection (unless patient has been stable on continuous antiretroviral therapy for at least 6 months, with CD4 count \>/= 250 cells/mm3 and viral load \</= 200 copies/ml, on a test performed at screening or during the last 12 months prior to screening, in which case they may be enrolled) 14. Use of any statin drug at screening or during the 3 months prior to screening 15. History of Atherosclerotic Cardiovascular Disease (ASCVD; defined as myocardial infarction, stable or unstable angina, coronary artery disease or coronary or other arterial revascularization, stroke, transient ischemic attack, or peripheral artery disease including aortic aneurysm, all of atherosclerotic origin) 16. Known Familial Hypercholesterolaemia 17. Other reasons, in the opinion of the investigator (and taking into consideration current local and international guidelines for primary prevention of cardiovascular disease), why the patient should commence statin treatment during the 6-month period following randomization 18. Current use of drugs contraindicated for use with rosuvastatin or standard TB drugs including fusidic acid, gemfibrozil, feno-fibrate, nicotinic acid (\>1 gram/day), cyclosporine, directly acting antivirals for chronic Hepatitis C, protease inhibitors for HIV and praziquantel. 19. Women who are pregnant or breastfeeding 20. Women of childbearing potential unwilling or unable to use appropriate effective contraception for the first 12 weeks of the trial. 21. Any serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis (such as extensive surgery, significant trauma, uncontrolled seizures) 22. Any other severe underlying condition that would, in the opinion of the investigator, compromise the patient's safety or outcome in the trial. 23. Participation in other clinical intervention trial or research protocol (participation in other studies that do not involve an intervention may be allowed, but this must be discussed and approved by the Chief Investigator).