Ocular-vestibular Biomarker Identification for ADHD

Sync-Think, Inc.240 enrolled

Overview

This study intends to establish a relationship between oculovestibular eye tracking measures, measures of ADHD, and medication prescribed for ADHD.

This study will use a predictive visual tracking paradigm (SyncThink EYE-SYNC eye tracking paradigm) to dynamically capture the participants' attentional state. It will examine the validity of the eye tracking paradigm in identifying the disruption in attentional networks caused by ADHD by examining the association between eye tracking performances and well-established standardized measures of ADHD.

Study Type

OBSERVATIONAL

Enrollment

240

Conditions

ADHD - Combined Type ADHD ADHD Predominantly Inattentive Type ADHD, Predominantly Hyperactive - Impulsive

Interventions

EYE-SYNCDEVICE

Nystagmograph used to measure eye movement

Eligibility

Sex: ALLMin age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women ages 6-70 seeking evaluation and treatment for ADHD. Exclusion Criteria: * Clinical diagnosis of a neurological condition including the following: stroke, multiple sclerosis, epilepsy, brain tumor/cancer, dyslexia, nystagmus and/or other major neurological condition. * Clinical diagnosis of any of the following eye-sight abnormalities: uncorrected amblyopia, uncorrected myopia, uncorrected presbyopia, uncorrected farsightedness or uncorrected Astigmatism. * Psychiatric history with any of the following: * LIFETIME: Clinical diagnosis of a psychotic disorder; bipolar disorder * LAST YEAR: Clinical diagnosis of major depressive disorder; PTSD; clinical diagnosis of substance abuse disorder; major anxiety disorder * Use of a psychotropic medication * Impairment of cranial nerves II-VI * Participants who receive a 'Poor' or 'Fair' eye tracking quality result on either their baseline or follow-up evaluations will be excluded from analysis. Subjects may not repeat participation

Locations (1)

Palo Alto Medical Foundation - San Carlos Center

San Carlos, California, United States

RECRUITING

Outcomes

Primary Outcomes

Eye Tracking and ADHD measure correlation

Zero-order correlations among eye tracking parameters, CAARS ADHD indices, CBRS ADHD indices, and confounding variables

Time frame: through study completion, an average of 1 year

Eye Tracking ADHD Diagnostic ROC

Specific eye tracking parameters will be compared to determine which have the greatest diagnostic utility. Supervised machine learning models will be generated and optimized ROC AUC for both children and adults using eye tracking parameters as input and CAARS indices, CBRS indices, and clinical diagnosis as outcomes

Time frame: through study completion, an average of 1 year

MANCOVA Eye Tracking in ADHD Treatment Population

Repeated measures multivariate analysis of covariance (MANCOVA) will be used to compare eye tracking performance over time in adults and children with ADHD (medicated and unmedicated)

Time frame: through study completion, an average of 1 year

Central Contacts

Benjamin Cheyette, M.D.,Ph.D.

CONTACT

650.278.1814 cheyetbr@sutterhealth.org

Data from ClinicalTrials.gov

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