Quantitation of Glymphatic Functioning in Sleep and Meditative States

Vanderbilt University Medical Center75 enrolled

Overview

This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.

This study is evaluating the glymphatic system during awake, sleep, and meditative states.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Parkinson Disease Sleep

Interventions

MeditationBEHAVIORAL

meditation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ages 14-45 * "Adept meditator status" Exclusion Criteria: * Any non-MR compatible material implant, or contraindication to MR scanning * Claustrophobia or inability to lie still for prolonged periods of time * Participants with a recent (less than 2 months) infection, tattoo, or wound * No consumption of stimulants or alcohol within 12 hours of the study visit * clinical diagnosis of any major neurological or psychological condition * Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

CSF flow change

Using MRI to assess the change in CSF flow in awake, sleep deprived, and meditative states

Time frame: baseline to 24 hours

Secondary Outcomes

EEG changes

Looking at brain wave changes before and after intervention in Alpha, Beta, and Delta waves associated with light to deep sleep. The lowest bandwidth for alpha waves is 8 while the highest is 12. The lowest bandwidth for Beta waves is 13 Hz while the highest is 30 Hz. The lowest bandwidth for Delta waves is .4 Hz and the highest is 4 Hz.

Time frame: baseline to 24 hours

Data from ClinicalTrials.gov

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