Respiratory Muscle Training in ICU Patients

University of Liege100 enrolled

Overview

Respiratory muscle weakness is common after mechanical ventilation and occurs early. This can limit functional recovery. Respiratory muscle training is often neglected in clinical practice. Some data indicates that inspiratory muscle training increases inspiratory muscle strength and quality of life. The aim of the study is to assess the impact of combined inspiratory and expiratory muscle training on inspiratory muscle strength. The second aim is to assess the impact of this training program on expiratory muscle strength.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

100

Conditions

Critical Illness Inspiratory Muscle Strength Mechanical Ventilation Respiratory Muscle Training

inspiratory and expiratory muscle trainingPROCEDURE

inspiratory muscle training using threshold IMT device expiratory muscle training using a bottle filled of water

inspiratory and expiratory exercisesPROCEDURE

inspiratory exercise using fractionated inspirations expiratory exercise using a bottle filled with water at a minimum level

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient from mechanical ventilation after at least 24 hours of support * collaborative patient Exclusion Criteria: * confusion, mental disorder * not french speaking * pulmonary surgery in the past 12 months * external ventricular drain * previous pneumothorax or pneumothorax not drained * rib fractures * alveolar hemorrhage * hemodynamic instability * labial occlusion impossible (face burn, facial paralysis) * patient refusal

Locations (1)

University Hospital of Liège

Liège, Belgium

RECRUITING

Outcomes

Primary Outcomes

change in inspiratory muscle strength

measurement of maximal inspiratory pressure

Time frame: between 7 to 15 days after ICU discharge (compared to ICU discharge)

change in inspiratory muscle strength

measurement of maximal inspiratory pressure

Time frame: 1 month after ICU discharge (compared to ICU discharge)

Secondary Outcomes

change in expiratory muscle strength

measurement of maximal expiratory pressure

Time frame: between 7 to 15 days after ICU discharge (compared to ICU discharge)

change in expiratory muscle strength

measurement of maximal expiratory pressure

Time frame: 1 month after ICU discharge (compared to ICU discharge)

respiratory infections

number of respiratory infections requiring antibiotics after ICU discharge

Time frame: 1 month after ICU discharge

change in dyspnea perception

assessed using Dyspnea-12 questionnaire (score from 0 to 36, 36 indicating a maximal dyspnea)

Time frame: 1 month after ICU discharge (compared to hospital discharge)

impact of dyspnea on physical activities

assessed using modified Medical Research Council (m-MRC) score: stage 0 to 4 (last stage indicating a patient too dyspneic to leave house or breathless when dressing)

Time frame: between 7 to 15 days after ICU discharge

impact of dyspnea on physical activities

assessed using modified Medical Research Council (m-MRC) score: stage 0 to 4 (last stage indicating a patient too dyspneic to leave house or breathless when dressing)

Time frame: 1 month after ICU discharge

Central Contacts

Anne-Françoise Rousseau, MD, PhD

CONTACT

+3243667495 afrousseau@chuliege.be

Data from ClinicalTrials.gov

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