Palonosetron and Blood Coagulation

Seoul National University Bundang Hospital12 enrolled

Overview

Palonosetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of palonosetron. The investigators therefore will perform the present study to measure the effect of palonosetron levels using thromboelastography.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Blood Coagulation Disorder

Interventions

0 ul of palonosetronDRUG

Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 ul) using palonosetron

1 ul of palonosetronDRUG

Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (1 ul) using palonosetron

10 ul of palonosetronDRUG

Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (10 ul) using palonosetron

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Age: 20 to 65 years * Body weight \> 50 kg * Volunteers who provided informed consent Exclusion Criteria: * Hematologic disease * Anticoagulant medication

Locations (1)

Seoul National Univ. Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

RECRUITING