Effects of MET-3 and MET-5 on Gut Microbiome and Metabolic Function in Men and Women With Hypertriglyceridemia

Inclusion Criteria: 1. Male or non-pregnant, non-lactating females who are taking adequate contraceptive precaution, aged 18 to 49 years inclusive; 2. Body Mass Index (BMI) ≥25.0 kg/m2 and ≤40.0 kg/m2; 3. Stable body weight (±4 kg) for the past 4 months with no intention to gain or lose weight; 4. Fasting serum triglycerides ≥1.5 mmol/L (133 mg/dL) and \<8 mmol/L (\<709 mg/dL) at screening; 5. Fasting serum glucose \<7.0 mmol/L (\<126 mg/dl); 6. HbA1c \<6.5% at screening; 7. Blood pressure \<160/100; 8. AST, ALT and ALP ≤3 times the upper limit of normal (liver function) at screening; 9. Serum creatinine \< 1.5 times the upper limit of normal (kidney function) at screening; 10. Willing to maintain habitual diet, physical activity pattern, and body weight throughout the trial; 11. Willing to refrain from taking probiotic supplements throughout the trial; 12. Willing to abstain from strenuous exercise, consuming alcoholic drinks 24 hours before study days and during study days; 13. Willing to maintain current dietary supplement and medication use throughout the trial. On test days, subject agrees to bring any dietary supplements or medications taken in the morning with them to the clinical site to take just prior to the glucose test meal; 14. Subject is not currently participating nor recently (within 30 days of screening) participated in a clinical trial involving long-term exposure (greater than 24 hours) to an investigational drug, nutritional supplement or lifestyle modification; 15. Understanding the study procedures and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator and other authorized agents as indicated in the consent form. Exclusion Criteria 1. Failure to meet any one of the inclusion criteria. 2. Smokers 3. Known history of AIDS, hepatitis, a history or presence of clinically important endocrine conditions (including Type 1 or Type 2 diabetes mellitus), pulmonary, biliary or gastrointestinal (GI) disorders or new onset cardiovascular disease within 6 months of screening (including, but not limited to, atherosclerotic disease, history of myocardial infarction, peripheral arterial disease, stroke). 4. Use of antibiotics within 1 week of screening. 5. Use of probiotic supplements within 1 week of screening. 6. Use of medications known to influence carbohydrate metabolism, GI function or appetite, including, but not limited to adrenergic blockers, diuretics, thiazolidinediones, metformin and systemic corticosteroids within 4 weeks of the screening visit, or with any condition which might, in the opinion of the Investigator, either: a) make participation dangerous to the subject or to others, b) affect the results, or c) influence the ability of the subject to comply with study procedures. 7. Major trauma or surgical event within 3 months of screening. 8. Unwillingness or inability to comply with the experimental procedures and to follow study safety guidelines. 9. Known intolerance, sensitivity or allergy to any ingredients in the investigational agent. 10. Extreme dietary habits, as judged by the Investigator (i.e. Atkins diet, very high protein diets, etc.). 11. History of cancer in the prior two years, except for non-melanoma skin cancer. 12. Recent history (within 12 months of screening) or strong potential for alcohol or substance abuse. Alcohol abuse is defined as \> 14 drinks per week (1 drink=12 oz beer, 5 oz wine, or 1.5 oz distilled spirits). 13. Pregnancy or breastfeeding.