Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

Istanbul University - Cerrahpasa

Overview

Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Study Type

OBSERVATIONAL

Conditions

Respiratory Distress Syndrome, Adult Ventilation Perfusion Mismatch Pulmonary Edema Covid19

Interventions

Extravascular Lung Water IndexDEVICE

Measurement of the EVLWI

Pulmonary Vascular Permeability IndexDEVICE

Measurement of the PVPI

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ARDS defined by Berlin Criteria longer than 24 hours * Undergoing mechanical ventilation * Noradrenaline demand \>0.1 mcg/kg/min Exclusion Criteria: * Not meeting ARDS criteria * Noninvasive mechanical ventilation * ARDS resolved shorter than 24 hours * Shock resolved

Locations (1)

Istanbul University-Cerrahpaşa

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Extravascular Lung Water Index

The amount of fluid accumulated in the lung measured by transpulmonary thermodilution (ml/kg)

Time frame: 1 day

Pulmonary vascular permeability index

Integrity of the alveolocapillary barrier measured by transpulmonary thermodilution

Time frame: 1 day

Data from ClinicalTrials.gov

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