Clinical Study of Liposomal Mitoxantrone Hydrochloride Injection Combined With Pegaspargase in the Treatment of NKTCL

Inclusion Criteria: 1. Subjects fully understand and voluntarily participate in this study and sign informed consent; 2. Age ≥18, ≤75 years, no gender limitation; 3. Histologically confirmed diagnosis of treatment-naïve, relapsed or refractory extranodal NK/T-cell lymphoma nasal type (NKTCL); 4. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1 5. At least one measurable lesion as per Lugano 2014 criteria; 6. Adequate bone marrow, liver, renal and coagulation function Exclusion Criteria: 1. Known central nervous system involvement caused by lymphoma; 2. Known infiltration of the bone marrow according to criteria for leukemia (≥20% myeloblast in the blood or bone marrow); 3. Known hemophagocytic syndrome; 4. History of allergy and contraindications to mitoxantrone hydrochloride and/or asparaginase/ pegaspargase; 5. Chemotherapy, radiotherapy, biotherapy, endocrine therapy, targeted therapy, immunotherapy and other anti-tumor treatment within 4 weeks of the first dose of the study drug (2 weeks for the local radiation therapy for pain relief); 6. Life expectancy \< 3 months 7. Impaired cardiac function or serious cardiac disease; 8. Known hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) or other active viral infection; 9. Acute symptomatic or chronic pancreatitis within 4 weeks prior to screening; 10. History of, or known additional tumor (exception: non-melanoma skin cancer (in situ) and cervical cancer (in situ) which have been cured and have not recurred within 5 years); 11. History of solid organ transplantation, autologous hematopoietic stem cell transplantation within 6 months prior to screening, or allogeneic hematopoietic stem cell transplantation before screening; 12. Major surgery within 4 weeks prior to screening. Or have a surgical schedule during the study period; 13. A serious infection within 4 weeks prior to screening and not suitable for the study according to the judgment of the investigator; 14. Uncontrolled diabetes at screening; 15. Known alcohol or drug abuse; 16. Known psychiatric disorders or cognitive disorder; 17. 17\. Pregnant or breastfeeding women, or patients who are expecting to conceive or father in 12 months (starting with the screening visit)； 18. Not suitable for this study as determined by the investigator due to other reasons.