Plant-Based Meat vs Animal "Red" Meat Trial

McGill University Health Centre/Research Institute of the McGill University Health Centre41 enrolled

Overview

To assess the changes in the circulating levels of TMAO after 1-week of beef or plant-based burger diet.

Single-center, randomized, single-blinded cross-over trial including healthy adult participants (N=40, omnivores, aged between 25 and 65 years, and with a body mass index (BMI) between 20 and 40 kg/m2 (see participation criteria below). Participants will be randomized to either red meat (cow burger) or plant "meat" (plant-based burger). The primary outcome will be the within-group change in the TMAO levels.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Inflammatory Response

Interventions

Red meat patties groupOTHER

1\. Baseline Visit: day -7 before randomization * Clinical history * Refrain from seafood, eggs, fish or meat, for 7-day ("washout") prior to Day 1. 2. Day 1 Randomization * Randomization to 1 of 2 interventions: plant-based or meat burgers * 6 days-worth of burgers will be delivered to the participant's house 3. Day 1-6: * The participant will be asked to eat a specific randomized diet for 6 days 5. Days 7 * Physical exam (weight, BP, HR) * Food questionnaire * Blood draw: Circulating TMAO, Total, LDL, and HDL cholesterol, Creatinine, High-sensitivity c-reactive protein * Urine Collection - TMAO 6. Day 7-14: Washout 7. Day 14: Patties delivery 8. Day 14-20: Assigned diet for 6 days 9. Days 20: Same as day 7

Plant-based patties groupOTHER

Same as above

Eligibility

Sex: ALLMin age: 25 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ≥ 25 years and ≤65 of age * BMI ≥20 Kg/m2 and ≤40 Kg/m2 * No known kidney disease * No antibiotics in the previous 30 days Exclusion Criteria: * Any person who does not meet the above criteria and/or who refuses to participate * Food allergies (specific ingredients contained in the patties)

Locations (1)

McGill University health Center

Montreal, Quebec, Canada