Does Adding Magnesium Sulphate to Low Dose Rocuronium Affects Depth of Blockade

National Cancer Institute, Egypt60 enrolled

Overview

This study aim is to compare the effect of magnesium sulphate combined with low dose rocuronium versus standard dose rocuronium

Comparing the effect of magnesium sulphate combined to low dose rocuronium versus standard dose rocuronium in cancer patients undergoing direct laryngoscopy for laryngeal tumors regarding intubating conditions, intraoperative relaxation, depth of anesthesia and recovery time.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Anesthesia

Interventions

standard rocuronium doseDRUG

0.6 mg/kg rocuronium during induction of anesthesia

Magnesium sulfateDRUG

50 mg/kg magnesium sulphate added to 0.40 mg/kg rocuronium

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients with Laryngeal tumors ASA I-II Age 30-70 years Exclusion Criteria: Renal and or hepatic insufficiency Neuromuscular disease Large glottic and/or supra-glottic lesions with or without breathing difficulties Known allergy to any of the used drug

Locations (1)

National Cancer Institute

Cairo, Egypt

Outcomes

Primary Outcomes

Onset and duration of muscle relaxant

Onset time of muscle relaxant and duration

Time frame: 90 minutes

Secondary Outcomes

Degree of muscle relaxation

depth of blockade

Time frame: 90 minutes

Data from ClinicalTrials.gov

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