This is an open-label, Phase 2/3,multicenter and single-arm clinical trial of Camrelizumab plus decitabine for Anti-PD-1 treatment-naive patients with relapsed or refractory Hodgkin Lymphoma. The primary objective of this study is to evaluate the long-term response duration with Camrelizumab plus decitabine in relapsed or refractory Hodgkin Lymphoma.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Decitabine is an investigational (experimental) drug that works by depleting DNA methyltransferase 1 (DNMT1), which can increase tumor antigens and HLA expression, enhances antigen processing, promotes T cell infiltration, and boosts effector T cell function. Camrelizumab is a humanized anti-PD-1 monoclonal antibody.
Biotherapeutic Department and Hematology Department of Chinese PLA General Hospital
Beijing, China
RECRUITINGduration of response
Time measured from the day of first documented PR or CR to the date of first documented progression, or death from any cause.
Time frame: 5 years
Progression free survival
Time measured from the day of treatment to the date of first documented progression, or death from any cause
Time frame: 5 years
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